Endocrine Abstracts

Background: Copeptin is the C-terminal portion of the precursor of vasopressin. In contrast to vasopressin copeptin is stable in vitro and easy to measure. Similar kinetics of both peptides have been described in different trials. However, the physiological area of normality of copeptin has never been evaluated.Methods: We measured plasma copeptin, sodium, and osmolality levels in 93 healthy volunteers at baseline, during/after i.v. infusion of ...

Objectives: Graves’ disease (GD) is characterized by variable disease severity at diagnosis and variable disease activity during follow-up. Antithyroid drugs (ATD) such as carbimazole (CMZ), methimazole or propylthiouracil are the first-line treatment. Current guidelines recommend a range of ATD starting dose according to GD severity, followed by dose titration until euthyroidism is reached and a maintenance dose for a specific patient is established. As thyroid hormones ...